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Antibodies

FKBP52 Antibody, Clone Hi52C: PerCP

Product Sizes
100 ug
SMC-139D-PCP-100UG
About this Product
SKU:
SMC-139D-PCP
Additional Names:
FK506 binding protein 4 Antibody, FKBP4 Antibody, FKBP59 Antibody, HBI Antibody, HSP56 Antibody, p52 Antibody, p59 Antibody, PPIase Antibody, Rotamase Antibody, T cell FK506 binding protein Antibody
Application:
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Buffer:
PBS
CE/IVD:
RUO
translate.label.attr.clone:
Hi52C
Clonality:
Monoclonal
Conjugate:
PerCP
Concentration:
1 mg/ml
Extra Details:
HSP90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones (1). One class of HSP90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an HSP90 binding site. Among the TPR cochaperones of HSP90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin A-binding families of immunophilins (2). FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex (3). The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the HSP90 (4). Although FKBP52 and FKBP51 share ~75% sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different HSP90-binding characteristics (3). FK506 binding protein 51 kDa (FKBP51 or otherwise referred to as FKBP54) has been identified as a progestininducible gene. This protein is predominantly expressed in murine T cells but in humans, it is abundantly expressed in numerous tissues at levels many times higher than FKBP12. The FKBP51 gene is known to be induced by glucocorticoids (5).
Host:
Mouse
Immunogen:
Synthetic peptide corresponding to the residues of human FKBP52
Isotype:
IgG2a
Purification:
Protein G Purified
Reactivities:
Canine, Hamster, Human, Mouse, Rat
Shipping Conditions:
Blue Ice
Specificity:
Detects ~52kDa. Heavy chain migrates close to FKBP52 on SDS PAGE.
Storage Conditions:
See Manual
Supplier:
StressMarq Biosciences
Type:
Antibody: Monoclonal Antibody