DMPO Antibody
Product Sizes
100 ug
200-301-F21-100UG
About this Product
- SKU:
- 200-301-F21
- Additional Names:
- 5,5-dimethyl-2-(8-octanoic acid)-1-pyrroline N oxide
- Application:
- ELISA, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
- Buffer:
- 0.01 M Tris Cl, 0.15 M Sodium Chloride, 0.001 M EDTA
- CE/IVD:
- RUO
- translate.label.attr.clone:
- N1664A
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- The formation of free radicals and other highly reactive oxygen species has been implicated in the pathogenesis of many disease states. The ability to identify these species is crucial, and spin trapping has accomplished this goal. DMPO (5,5-dimethyl-1-pyrroline N-oxide) is one of the least toxic to cells and animals, and possesses convenient pharmacokinetics (uptake, distribution, metabolism and excretion) in biological systems. Recent studies have determined that nitric oxide may substantially affect the quantitative determination of DMPO adducts, and therefore extra caution is required when studying generation of these species in the presence of nitric oxide or its radicals. DMPO adducts can be generated with protein and DNA radicals.
- Formulation:
- 0.01 M Tris Cl, 0.15 M Sodium Chloride, 0.001 M EDTA, pH 7.4
- Host:
- Mouse
- Immunogen:
- DMPO Antibody was produced in mice by repeated immunizations with 5,5-dimethyl-2-(8-octanoic acid)-1-pyrrolone-N-oxide conjugated to Ovalbumin.
- Isotype:
- IgG1
- Physical State:
- Liquid
- Reactivities:
- Wide/Non-species Specific
- Shipping Conditions:
- Dry Ice
- Specificity:
- Anti-DMPO Antibody was purified by Protein G chromatography. DMPO is species independent. This antibody recognizes DMPO, DMPO-octanoic acid, DMPO-protein adducts and DMPO-DNA adducts. Does not cross react with non-adducted proteins or DNA. Cross-reactivity with DMPO from other sources has not been determined. Neuroscience research.
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.rockland.com/search/?searchString=200-301-F21
