Alpha B Crystallin Antibody
Product Sizes
200 ug
200-301-E86-200UG
About this Product
- SKU:
- 200-301-E86
- Additional Names:
- AACRYA, CRYA2, CRYAB, CTPP2, HspB5, NY Ren 27 antigen antibody, alpha crystallin B antibody, Heat shock protein beta-5, Renal carcinoma antigen NY-REN-27, Rosenthal fiber component|CRYAB
- Application:
- ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- CE/IVD:
- RUO
- translate.label.attr.clone:
- 3A10.H4
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- The alpha-crystallins are major water-soluble lens structural proteins of the vertebrate eye that are related to the small heat shock protein family. The alpha-crystallins possess structural and functional similarities with Hsp25 and Hsp27. Mammalian lens cystallins are divided into alpha, beta and gamma families. Alpha and beta families are further divided into acidic and basic groups (Alpha-A and Alpha-B respectively). In the lens, alpha-crystallin primarily functions to maintain proper refractive index, however it can also function as a molecular chaperone that binds to the denatured proteins, keeping them in solution and thereby maintaining the translucency of the lens. When cellular stress occurs, alpha-crystallin enters its' phosphorylated state and may serve a structural control function and play a role in protein maintenance. In addition to their interaction with proteins, alpha-crystallins also interact with native molecules such as membrane proteins, Golgi matrix protein, structural proteins, nuclear proteins and DNA. Two other functions are an autokinase activity and participation in the intracellular architecture, and it has also been proven that both alpha-A and B prevent apoptosis by inhibiting caspases. Specifically, alpha-B cystallin is found in many cells and organs outside the lens, and alpha B is overexpressed in several neurological disorders and in cell lines under stress conditions.
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Host:
- Mouse
- Immunogen:
- Alpha B Crystallin Antibody was produced in mice by repeated immunizations with Native Alpha B Crystallin protein.
- Isotype:
- IgG1
- Physical State:
- Liquid
- Reactivities:
- Bovine, Human
- Shipping Conditions:
- Dry Ice
- Specificity:
- Anti-Alpha B Crystallin Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Alpha B Crystallin from Human and bovine based on 100% homology with the immunizing sequence. Does not cross-react with A AlphaA-crystallin, B BetaL-crystallin, B BetaH-crystallin, G Gamma-crystallin, Hsp25, Hsp27 or Hsp47 proteins. Cross-reactivity with Alpha B Cry
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.rockland.com/search/?searchString=200-301-E86
