CCAR2 Polyclonal Antibody
Product Sizes
CCAR2 Polyclonal Antibody
RD252105A-200UL
About this Product
- SKU:
- RD252105A-200UL
- Additional Names:
- CCAR2,Cell cycle and apoptosis regulator 2,Cell division cycle and apoptosis regulator protein 2,DBC-1,DBC.1,DBC1,DBIRD complex subunit KIAA1967,Deleted in breast cancer 1,Deleted in breast cancer gene 1 protein,K1967,KIAA1967,NET35,p30 DBC,p30 DBC protein,p30DBC
- Application:
- ELISA, Immunohistochemistry
- Buffer:
- PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
- Concentration:
- 1.08 mg/ml
- Extra Details:
- Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:18235501, PubMed:18235502, PubMed:19131338, PubMed:19218236, PubMed:22446626, PubMed:23352644, PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978).
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide of human CCAR2
- Isotype:
- IgG
- Protein Details:
- Q8N163
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Size:
- 200 ul
- Supplier:
- Reddot
- Type:
- Antibody
- Synonyms:
- Cell division cycle and apoptosis regulator protein 2;DBIRD complex subunit KIAA1967;Deleted in breast cancer gene 1 protein;NET35;p30 DBC
- Manufacturer's Data Sheet:https://www.reddotbiotech.ca/antibodies/product/31147/CCAR2_Polyclonal_Antibody/