CD4 monoclonal antibody (GK 1.5), InVivoPure
Product Sizes
1 mg
AK3602P-1MG
5 mg
AK3602P-5MG
25 mg
AK3602P-25MG
50 mg
AK3602P-50MG
100 mg
AK3602P-100MG
About this Product
- SKU:
- AK3602P
- Additional Names:
- T-cell surface glycoprotein CD4, Cd4, T-cell differentiation antigen L3T4, T-cell surface antigen T4/Leu-3
- Application:
- Depletion
- Buffer:
- PBS
- translate.label.attr.clone:
- GK 1.5
- Clonality:
- Monoclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- The monoclonal antibody GK1.5 reacts with the mouse CD4 molecule, a 55 kDa cell surface receptor expressed by the majority of thymocytes, a subpopulation of mature T cells and dendritic cells. CD4 binds to MHC class II on the surface of antigen-presenting cells and plays an important role both in the development of T cells and in the optimal function of mature T cells. In T cells, CD4 associates with the protein tyrosine kinase p56lck via its cytoplasmic tail. The binding of GK1.5 is blocked by the antibody RM4-5, which competes with GK1.5 for the same binding site on the CD4 molecule. GK1.5 significantly increased the proportion of peripheral CD4+CD25+Foxp3+ Treg cells in CD4+ T cells in mice without altering their immunosuppressive function. The antibody profoundly blocks antigen-specific reactive mouse helper T lymphocyte lines of class II MHC.
- Formulation:
- Clear Liquid, PBS, pH 7.4, 0.2 um sterile filtered
- Host:
- Mouse
- Immunogen:
- Animals were immunized with the cloned cytotoxic T lymphocyte lines V4 and 243/2.5. L3T4 is expressed on mouse helper/inducer T cells and is analogous to the human Leu-3/T4 molecule.
- Isotype:
- IgG2b, kappa
- Physical State:
- Liquid
- Purity:
- >=90%
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- InVivo Biotech Services GmbH
- Type:
- Antibody: In Vivo Antibodies
- Shipping Costs:
- Free Shipping to the UK
- Main Competitor:
- This product is an equivalent to the main competitor item
