FLIP Alpha Antibody
Product Sizes
100 ug
200-401-983-100UG
About this Product
- SKU:
- 200-401-983
- Additional Names:
- c FLIP antibody, c FLIPL antibody, c FLIPR antibody, c FLIPS antibody, CASH antibody, CASP8 and FADD like apoptosis regulator antibody, CASP8 and FADD like apoptosis regulator precursor antibody, CASP8 antibody, CASP8AP1 antibody, FLIP-L; CLARP1; MRIT alpha-1; CASH alpha; I-FLICE 1; FLAME-1 gamma|CFLAR
- Application:
- ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- CE/IVD:
- RUO
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Apoptosis is related to many diseases and is induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE/CED-3 protease family. Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the ICE/CED-3 protease family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and FLIP, respectively. The human FLIP was also cloned by several labs independently and termed Casper, I-FLICE, FLAME-1, CASH and CLARP. FLIP contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with adapter protein FADD and caspase-8 and -10, and potently inhibits apoptosis induced by all known death receptors. Four splice variants of FLIPs have been identified and termed FLIP A Alpha, B Beta, G Gamma, and D Delta, respectively. Anti-FLIP antibody is ideal for investigators involved in Apoptosis, Cytokines and Growth factor research.
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Host:
- Rabbit
- Immunogen:
- FLIP Antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the carboxyl terminus of the human FLIPA Alpha/FLIPL protein.
- Isotype:
- IgG
- Physical State:
- Liquid
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Dry Ice
- Specificity:
- Anti-FLIP Antibody is affinity chromatography purified via peptide column. The product was purified from monospecific antiserum by DEAE ion exchange chromatography. The antibody is human, mouse and rat reactive and is specific for the a splice variant. Reactivity against homologues from other sources has not been determined.
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:https://www.rockland.com/search/?searchString=200-401-983
