ssK36
About this Product
- SKU:
- SP-010
- Additional Names:
- ssK36 (29-43)|ssK36, APRFGGVKRPNRYRP, H-APRFGGVKRPNRYRP-OH, ssK36 (29-43), SETD2, substrate, SP-010, SP010
- Extra Details:
- ssK36, or ssK36 (29-43), is a SET-domain containing protein 2 (SETD2) super substrate. SETD2, also called KMT3A, was first identified as huntingtin interacting protein 1 (HYPB, HIP-1) and can add up to three methyl groups to K36 of histone H39 (H3K36). ssK36 (29-43 has been derived from the currently used SETD2 substrate peptide H3K36 (29-43) but is methylated about 290-fold faster, making it a super substrate. The increased methylation of ssK36 is due to an increase in the rate of catalysis and only to a smaller degree to improved binding.
- Immunogen:
- Histone methyltransferases
- Molecular Weight:
- 1771
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- Schuhmacher et al (2020) Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate. Commun. Biol.<strong> 3</strong>(1) 511 doi:10.1038/s42003-020-01223-6
- Sequence:
- H-Ala-Pro-Arg-Phe-Gly-Gly-Val-Lys-Arg-Pro-Asn-Arg-Tyr-Arg-Pro-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water and physiological buffers
- Formula:
- C79H127N29O18
