Anti Collagen Alpha-1(XVII) Chain (BP180/BPAG2) monoclonal antibody (Clone C34)
Product Sizes
500 ul
CAC-NU-01-BP2-500UL
About this Product
- SKU:
- CAC-NU-01-BP2
- Application:
- IHC-Frozen, Immunofluorescence, Immunoprecipitation, Western Blot
- translate.label.attr.clone:
- Clone c34
- Clonality:
- Monoclonal
- Extra Details:
- Hemidesmosomes are adhesive structures between cells and the extracellular matrix. They play a role in anchoring intermediate fibers to the extracellular basement membrane. Structurally, hemidesmosomes occur in two forms: Type I and Type II. Type I hemidesmosomes develop in stratified epithelia such as the epidermis. Its main components include the intracellular linker proteins Plectin and BPAG1, the adhesion receptor integrin A Alpha6B Beta4 and collagen type BP180/XVII. Type II hemidesmosomes occur in blood vessels, Schwann cells, and digestive tract epithelia as a simplified form of Type I hemidesmosomes, consisting only plectin and integrin A Alpha6B Beta4. The hemidesmosomal adhesion receptor is normally associated with Laminin 5 in the basement membrane. Furthermore, Laminin 5 (of which Laminin gamma 2 is a subunit) is linked to collagen fibers in the dermis via type VII collagen. Genetic deletion of hemidesmosome-related proteins causes various forms of epidermolysis bullosa, highlighting their importance in promoting adhesion between the epidermis and the basement membrane. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. References: 1) Yamauchi T., et al. J. Dermatol. Sci., 76:25-33 (2014). 2) Hirako Y., et al. Exp. Cell Res., 324:172-182 (2014). 3) Hirako Y., et al. J. Baiol. Chem., 273:9711-9717 (1998)., CAC
- Host:
- Mouse
- Immunogen:
- Collagen Alpha-1(XVII) Chain (BP180/BPAG2)
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- Cosmo Bio Ltd
- Type:
- Antibody: Monoclonal Antibody