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Antibodies

GABAA Receptor alpha 6 Antibody

Product Sizes
50 ul
100-401-D48-50UL
About this Product
SKU:
100-401-D48
Additional Names:
Gabra6|Gamma-aminobutyric acid receptor subunit alpha-6, GABA(A) receptor subunit alpha-6
Application:
Western Blot
CE/IVD:
RUO
Clonality:
Polyclonal
Extra Details:
Anti-GABA(A) Receptor alpha 6 Antibody detects GABA(A) Receptor alpha 6. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six A Alphas, four B Betas and four G Gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for A Alpha- and B Beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a G Gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different A Alpha-subunits of the receptor. Phosphorylation of B Beta-subunits of the receptor has been shown to modulate GABAA-R function. Anti-GABA(A) receptor alpha 6 antibody is ideal for investigators involved in Neuroscience.
Format:
Antiserum
Host:
Rabbit
Immunogen:
Anti-GABA(A) Receptor a 6 Antibody was produced by repeated immunizations with rat GABA(A) receptor alpha 6- Synthetic peptide corresponding to amino acid specific to the alpha 6 subunit.
Physical State:
Liquid
Reactivities:
Mouse, Rat
Shipping Conditions:
Dry Ice
Specificity:
Anti-GABA(A) Receptor alpha 6 Antibody is directed against rat GABA(A) Receptor alpha 6. The antibody was prepared from monospecific neat serum. This antibody is directed against rat GABA(A) Receptor alpha 6 proteins. Reactivity is expected from mouse. Cross reactivity with GABA(A) Receptor alpha 6 from other sources has not been determined.
Storage Conditions:
Please refer to datasheet
Supplier:
Rockland Inc
Type:
Antibody: Polyclonal Antibody
Western Blot of Rabbit Anti-GABA(A) Receptor alpha 6 (Rabbit) Antibody. Lane 1: rat cortex lysate. Lane 2: none. Load: 10 ug per lane. Primary antibody: GABA(A) Receptor alpha 6 antibody at 1:1000 for overnight at 4°C. Secondary antibody: IRDye800™ rabbit secondary antibody at 1:10,000 for 45 min at RT. Block: 5% BLOTTO overnight at 4°C. Predicted/Observed size: ~57k ,~57k for A Alpha6-subunit of the GABAA-R. Other band(s): none.