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Antibodies

DsbA-L Antibody

Product Sizes
100 ul
100-401-D29-100UL
About this Product
SKU:
100-401-D29
Additional Names:
Glutathione S-transferase kappa 1, GST 13-13, GST class-kappa, GSTK1-1, Glutathione S-transferase subunit 13, Disulfide-bond-A oxidoreductase-like protein, DsbA-L|Gstk1
Application:
ELISA, Immunohistochemistry, Western Blot
CE/IVD:
RUO
Clonality:
Polyclonal
Extra Details:
DsbA-L Antibody detects Disulfide-bond-A oxidoreductase-like protein (DsbA-L, previously named as GST Kappa) which is an adiponectin-interacting protein. DsbA-L is highly expressed in adipose tissue, and its expression level is negatively correlated with obesity in mice and humans. DsbA-L expression in 3T3-L1 adipocytes is stimulated by the insulin sensitizer rosiglitazone and inhibited by the inflammatory cytokine TNFalpha. Polymorphism of DsbA-L gene has recently been implicated in insulin secretion and body fat distribution. Overexpression of DsbA-L promotes adiponectin multimerization while suppressing DsbA-L expression by RNAi markedly and selectively reduces adiponectin levels and secretion in 3T3-L1 adipocytes. Recent studies identify DsbA-L as a key regulator for adiponectin biosynthesis. Anti-DsbA-L Antibody is ideal for investigators involved in Cell Signaling and Cell Metabolism.
Format:
Antiserum
Host:
Rabbit
Immunogen:
Anti-DsbA-L Antibody was produced in rabbit by repeated immunizations with full length recombinant mouse DsbA-L protein
Physical State:
Liquid
Reactivities:
Human, Mouse
Shipping Conditions:
Dry Ice
Specificity:
Anti-DsbA-L antibody is directed against DsbA-L. Anti-DsbA-L antibody is neat antiserum prepared from monospecific antiserum by delipidation and defibrination. Reactivity against DsbA-L occurs from mouse and human sources. Reactivity against DsbA-L from other sources is unknown.
Storage Conditions:
Please refer to datasheet
Supplier:
Rockland Inc
Type:
Antibody: Polyclonal Antibody
Western Blot of Rabbit Anti-DsbA-L Antibody. Lane 1: mouse adipose tissue. Lane 2: none. Load: 10 ug per lane. Primary antibody: DsbA-L antibody at 1:1000 for overnight at 4°C. Secondary antibody: IRDye800™ rabbit secondary antibody at 1:10,000 for 45 min at RT. Block: 5% BLOTTO overnight at 4°C. Predicted/Observed size: ~25 kDa, ~25 kDa for DsbA-L protein. Other band(s): none.