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Proteins and Peptides

FRP-5, soluble

Product Sizes
10ug
£178.82
S01-077S-10UG
About this Product
SKU:
S01-077S
Additional Names:
Secreted frizzled‐related protein 5, Frizzled‐related protein 1b, FRP‐1b, Secreted apoptosis‐related protein 3, SARP‐3
translate.label.attr.clone:
Goat IgG
Extra Details:
HAI1 is a Kunitz-type serine protease inhibitor, identified as a strong inhibitor of HGF activator (HGFA) and matriptase. The membrane anchored HAI1 consists of two Kunitz domains, a LDL receptorlike domain, and a C-terminal transmembrane domain. Two soluble forms are generated by ectodomain shedding, one with a single Kunitz domain and the other with two Kunitz domains. HAI1 is not only an inhibitor but also a specific receptor of active HGFA, acting as a reservoir of this enzyme on the cell surface . The shedding of HAI1 and HGFA/HAI1 complex is enhanced by treatment with phorbol 12-myristate 13-acetate or IL1β. The regulated shedding is completely inhibited by a synthetic zinc metalloprotease inhibitor.
Formulation:
lyophilized
Host:
E. coli
Shipping Conditions:
Ambient
Storage Conditions:
Room Temperature
Supplier:
ReliaTech