Bak BH3
About this Product
- SKU:
- PP-060
- Additional Names:
- Bak BH3 peptide, BAK peptide
- CAS Number:
- 300349-67-1
- Extra Details:
- Bak BH3 corresponds to amino acids 72 - 87 in the BH3 region of human Bak and is the miminal sequence for binding to Bcl-xL (B-cell lymphoma-extra large), a transmembrane molecule in the mitochondria which is a member of the Bcl-2 family and key regulator of apoptosis. Bak BH3 has high affinity binding to a surface pocket of the Bcl-XL protein that is essential for its death antagonist function. Bcl-2 is a potent suppressor of apoptosis, and its overexpression contributes to tumourigenesis in many types of human cancers.
- Molecular Weight:
- 1724.93
- Purity:
- >95% by hplc
- References:
- <p>Sattler et al (1997) Structure of Bcl-xL-Bak Peptide Complex: Recognition Between Regulators of Apoptosis. Science 14 Feb 1997 983<a href="https://pubmed.ncbi.nlm.nih.gov/9020082/" target="_blank" rel="nofollow"> PMID: 9020082</a></p><p>Childs et al (2007) Apoptotic signaling induces hyperpermeability following hemorrhagic shock. Am J Physiol Heart Circ Physiol. <strong>292</strong>(6) H3179-89 <a href="https://pubmed.ncbi.nlm.nih.gov/17307990/" target="_blank" rel="nofollow">PMID: 17307990</a></p><p>Frey et al (2008) Structure-activity relationships of Bak derived peptides: Affinity and specificity modulations by amino acid replacement, Eur. J. Medicinal Chemistry, <strong>43</strong>(5) 966 </p>
- Sequence:
- H-Gly-Gln-Val-Gly-Arg-Gln-Leu-Ala-Ile-Ile-Gly-Asp-Asp-Ile-Asn-Arg-OH
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble in DMSO
- Formula:
- C72H125N25O24