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Antibodies

Anti Nuclear Receptor Subfamily 5 Group A Member 1 (NR5A1) monoclonal antibody (Clone 1B1F10)

Product Sizes
50 ug
KAL-KO610-50UG
About this Product
SKU:
KAL-KO610
Application:
ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
translate.label.attr.clone:
Clone 1b1f10
Clonality:
Monoclonal
Extra Details:
UniProt Summary Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Transcription repressor of the Moloney leukemia virus long terminal repeat in undifferentiated murine embryonal carcinoma cells. Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular phosphatidyl(3,4)bisphosphate, phosphatidyl(3,5)bisphosphate and phosphatidyl(3,4,5)triphosphate. References 1) Shima Y, et al: Mol. Endocrinol. (2008)22:1633-1646 2) Yokoyama C, et al: HYBRIDOMA (2009)28(2):113-119*, KAL
Host:
Rat
Immunogen:
Nuclear Receptor Subfamily 5 Group A Member 1 (NR5A1)
Reactivities:
Mouse
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C
Supplier:
Cosmo Bio Ltd
Type:
Antibody: Monoclonal Antibody