SPN Antibody
Product Sizes
0.1 mg
OAEE00242-0.1MG
About this Product
- SKU:
- OAEE00242
- Additional Names:
- CD43;galactoglycoprotein;GALGP;GPL115;leukocyte sialoglycoprotein;leukosialin;LSN;Sialophorin;sialophorin (gpL115, leukosialin, CD43).|sialophorin
- Application:
- Flow Cytometry, IHC-Paraffin, Immunoprecipitation, Western Blot
- Buffer:
- TBS
- translate.label.attr.clone:
- MEM-59
- Clonality:
- Monoclonal
- Conjugate:
- Biotin
- Concentration:
- 1 mg/ml
- Extra Details:
- Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells (PubMed:18036228). Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (PubMed:24328034). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1 (By similarity).
- Formulation:
- Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
- Host:
- Mouse
- Immunogen:
- Human T lymphocytes.
- Isotype:
- IgG1
- Purification:
- Size-exclusion Chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- The antibody MEM-59 recognizes neuraminidase-sensitive epitope on CD43 (Leukosialin), a 95-135 kDa type I transmembrane glycoprotein (mucin-type) which is involved in lymphocyte activation. CD43 is expressed by platelets and at high levels on the surface of all leukocytes; it is negative on resting B lymphocytes and erythrocytes. HLDA IV; WS Code NL 604 HLDA V; WS Code AS S290
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php