Human CD204 / MSR1 ELISA Kit
Product Sizes
96 wells
£818.00
ARG83333-96WELLS
About this Product
- SKU:
- ARG83333
- Additional Names:
- MSR1; Macrophage Scavenger Receptor 1; SCARA1; SR-AIII; SR-AII; CD204; SR-AI; SR-A; Macrophage Scavenger Receptor Types I And II; Macrophage Acetylated LDL Receptor I And II; Scavenger Receptor Class A Member 1; Macrophage Scavenger Receptor Type III; CD204 Antigen; PhSR1; PhSR2; SRA
- Application:
- ELISA
- CE/IVD:
- RUO
- Conjugate:
- HRP
- Extra Details:
- This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
- Physical State:
- Cell Culture Supernatant, Plasma, Serum
- Range:
- 93.7 - 6000 pg/ml
- Sensitivity:
- 45 pg/ml
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Arigo Biolaboratories
- Type:
- Assay Kits: ELISAs
