Mouse WISP1 ELISA Kit
Product Sizes
96 wells
ARG81846-96WELLS
About this Product
- SKU:
- ARG81846
- Additional Names:
- CCN4; WISP-1; WISP1i; WISP1c; CCN family member 4; Wnt-1-induced secreted protein; WNT1-inducible-signaling pathway protein 1; WISP1tc
- Application:
- ELISA
- CE/IVD:
- RUO
- Conjugate:
- HRP
- Extra Details:
- This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011]
- Immunogen:
- WISP1
- Physical State:
- Cell Culture Supernatant, Plasma, Serum
- Reactivities:
- Mouse
- Sensitivity:
- 15.6 pg/ml
- Shipping Conditions:
- Blue Ice
- Specificity:
- There is no detectable cross-reactivity with other relevant proteins.
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Arigo Biolaboratories
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:ARG81846.html
