anti-CD45RA / RB antibody [MRC OX-33] (FITC)
About this Product
- SKU:
- ARG65846
- Additional Names:
- LY5; GP180; Receptor-type tyrosine-protein phosphatase C; CD45; L-CA; CD antigen CD45; Leukocyte common antigen; CD45R; LCA; T200; EC 3.1.3.48; B220
- Application:
- Flow Cytometry
- Buffer:
- PBS (pH 7.2), 0.09% Sodium azide and 1% BSA.
- CE/IVD:
- RUO
- translate.label.attr.clone:
- MRC OX-33
- Clonality:
- Monoclonal
- Conjugate:
- FITC
- Extra Details:
- CD45 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
- Host:
- Mouse
- Immunogen:
- Rat CD45RA / RB
- Isotype:
- IgG1
- Purification:
- Purified
- Reactivities:
- Rat
- Shipping Conditions:
- Blue Ice
- Specificity:
- The rat CD45 antigen (Leukocyte Common Antigen (L-CA)) has been shown to exist in different forms on different lymphoid cell types. CD45 on Thymocytes shows one main band at 180 kDa, T cells show 4 bands at 180, 190, 200 and 220 kDa. It detects a subfraction of the 240 kDa rat CD45 band found only on B lymphocytes.
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Arigo Biolaboratories
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:ARG65846.html