anti-HLA DP + DR antibody [HL-40]
About this Product
- SKU:
- ARG63012
- Additional Names:
- MHC class II antigen DPB1; HLA-DP1B; HLA-DP; HLA class II histocompatibility antigen, DP; W4; DPB1; HLA class II histocompatibility antigen, DP beta 1 chain; HLA-DPB
- Application:
- Flow Cytometry, IHC-Paraffin, Immunoprecipitation
- Buffer:
- PBS (pH 7.4) and 15 mM Sodium azide
- CE/IVD:
- RUO
- translate.label.attr.clone:
- HL-40
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]
- Host:
- Mouse
- Immunogen:
- Raji Burkitt's lymphoma cell line
- Isotype:
- IgG2a
- Purity:
- >95%
- Purification:
- Protein A Purified
- Reactivities:
- Human, Porcine
- Shipping Conditions:
- Blue Ice
- Specificity:
- The clone HL-40 reacts with common epitope on beta-chain of human HLA-DR and HLA-DP. DR and DP are the isotypes of human MHC Class II molecules expressed on antigen-presenting cells (APC; dendritic cells, B lymphocytes, monocytes, macrophages).
- Storage Conditions:
- -20[o]C
- Supplier:
- Arigo Biolaboratories
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:ARG63012.html
