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Antibodies

anti-ALK antibody

Product Sizes
100 ul
ARG58060-100UL
Academic Pricing
Please contact us for academic pricing.
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About this Product
SKU:
ARG58060
Additional Names:
CD antigen CD246; Anaplastic lymphoma kinase; CD246; ALK tyrosine kinase receptor; EC 2.7.10.1; NBLST3
Application:
IHC-Paraffin, Immunocytochemistry, Immunofluorescence
Buffer:
PBS (pH 7.4), 150mM NaCl, 0.02% Sodium azide and 50% Glycerol.
CE/IVD:
RUO
Clonality:
Polyclonal
Extra Details:
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]
Host:
Rabbit
Immunogen:
Synthetic peptide derived from Human ALK.
Isotype:
IgG
Purification:
Affinity Purified
Reactivities:
Human, Mouse, Rat
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C
Supplier:
Arigo Biolaboratories
Type:
Antibody: Polyclonal Antibody