anti-Collagen I, alpha 1 propeptide (Procollagen I) antibody
About this Product
- SKU:
- ARG52247
- Additional Names:
- OI1; OI2; OI3; OI4; EDSC; Collagen alpha-1(I) chain; Alpha-1 type I collagen
- Application:
- IHC-Paraffin, Immunocytochemistry, Immunofluorescence, Western Blot
- Buffer:
- PBS
- CE/IVD:
- RUO
- Clonality:
- Polyclonal
- Extra Details:
- Collagen is an extracellular matrix protein that serves as a scaffold defining the shape and mechanical properties of many tissues and organs including skin, tendon, artery walls, fibrocartilage, bone and teeth. Type 1 collagen is the must abundant protein in mammals. Collagens are synthesized with N-terminal and C-terminal propeptides that are cleaved during maturation and secretion. After cleavage of the propeptides, the most N-terminal and C-terminal remaining sequences are known as telopeptides. Mutations in the collagen 1, alpha 1 gene (COL1A1) are known to cause osteogenesis imperfecta (aka brittle bone disease) (Byers 1989). Furthermore, mutations found in the fist 90 residues of the helical region of alpha 1 collagen have been implicated in the prevention or delayed removal of the procollagen N-propeptide leading to a combined osteogenesis imperfecta and Ehlers-Danlos syndrome (EDS) phenotype (Cabral et al., 2005).
- Host:
- Rabbit
- Immunogen:
- KLH-conjugated synthetic peptide corresponding to amino acid residues specific to the collagen I, alpha 1 propeptide.
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Amphibian, Avian, Fish, Human, Mouse, Other Mammal, Rat
- Shipping Conditions:
- Blue Ice
- Specificity:
- This antibody recognizes pro-collagen I, but not mature form of collagen I.
- Storage Conditions:
- -20[o]C
- Supplier:
- Arigo Biolaboratories
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:ARG52247.html
