anti-C4 / Complement 4 antibody
Product Sizes
100 ul
£593.00
ARG41935-100UL
About this Product
- SKU:
- ARG41935
- Additional Names:
- Complement C4-A; C4AD; CPAMD2; CO4; Acidic complement C4; C4S; C4A6; C4A4; RG; C4A2; C4A3; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; C4
- Application:
- Immunocytochemistry, Immunofluorescence, Western Blot
- Buffer:
- PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
- CE/IVD:
- RUO
- Clonality:
- Polyclonal
- Extra Details:
- This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain is cleaved to release C4 anaphylatoxin, an antimicrobial peptide and a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
- Host:
- Rabbit
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- Arigo Biolaboratories
- Type:
- Antibody: Polyclonal Antibody
