Biotinylated Cynomolgus / Rhesus macaque LRRC15 / LIB Protein, His,Avitag[TM]
Product Sizes
25 ug
£365.00
LR5-C82E7-25UG
200 ug
£1,565.00
LR5-C82E7-200UG
About this Product
- SKU:
- LR5-C82E7
- Additional Names:
- hLib|Leucine-rich repeat-containing protein 15|LIB|LRRC15
- Buffer:
- PBS, pH7.4
- Extra Details:
- LRRC15 (Leucine-rich repeat-containing protein 15) is also known as LIB and hLib. LRRC15 is highly expressed in a variety of solid tumors. LRRC15 was expressed on stromal fibroblasts in many solid tumors (e.g., breast, head and neck, lung, pancreatic) as well as directly on a subset of cancer cells of mesenchymal origin (e.g., sarcoma, melanoma, glioblastoma). LRRC15 expression was induced by TGFB Beta on activated fibroblasts (A AlphaSMA+) and on mesenchymal stem cells. These collective findings suggested LRRC15 as a novel CAF and mesenchymal marker with utility as a therapeutic target for the treatment of cancers with LRRC15-positive stromal desmoplasia or cancers of mesenchymal origin. ABBV-085 is a monomethyl auristatin E (MMAE)-containing antibody-drug conjugate (ADC) directed against LRRC15, and it demonstrated robust preclinical efficacy against LRRC15 stromal-positive/cancer-negative, and LRRC15 cancer-positive models as a monotherapy, or in combination with standard-of-care therapies.
- Molecular Weight:
- 61.6 kDa
- Physical State:
- Powder
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein