Cynomolgus / Rhesus macaque IL-4 R alpha / CD124 Protein, His Tag (MALS verified)
Product Sizes
50 ug
£377.00
ILR-C52H8-50UG
1 mg
£2,365.00
ILR-C52H8-1MG
About this Product
- SKU:
- ILR-C52H8
- Additional Names:
- CD124|IL4R|IL4RA
- Buffer:
- PBS, pH7.4
- Extra Details:
- IL-4 is a pleiotropic cytokine produced by activated Th2 cells and mast cells, and plays a pivotal role in immune responses. The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells. Hematopoietic cellular responses to IL-4 are mediated by a high affinity receptor complex comprised of the 140 kDa IL4RA Alpha (CD124)subunit and the 70 kDa common cytokine G Gammac chain (CD132). Interleukin 4 Receptor (IL4R) also known as CD124, IL4RA Alpha and BSF receptor, is a type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2--biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. IL4R can alternatively associate with IL-13Ra1 to form the type II receptor which is responsive to both IL-4 and IL-13. Interleukin-4 receptor has been shown to interact with SHC1.
- Molecular Weight:
- 25.6 kDa
- Physical State:
- Powder
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins