Human CD206 / MMR Protein, His Tag
Product Sizes
100 ug
£377.00
CD6-H52H9-100UG
1 mg
£2,753.00
CD6-H52H9-1MG
About this Product
- SKU:
- CD6-H52H9
- Additional Names:
- CD206|CLEC13D|CLEC13DL|hMR|MMR|MRC1|MRC1L1
- Buffer:
- PBS, pH7.4
- Extra Details:
- Mrc1 is a conserved checkpoint mediator protein that transduces the replication stress signal to the downstream effector kinase. Mrc1 and its vertebrate homologue Claspin serve as a mediator for replication stress checkpoint signaling, receiving the signal from Mec1/Rad3/ATR sensor kinase and transmitting it to the effector Rad53/Cds1/Chk1 kinase. The loss of mrc1 checkpoint activity results in the aberrant activation of late/dormant origins in the presence of hydroxyurea. Tumor-associated macrophages (TAMs) expressing the multi-ligand endocytic receptor mannose receptor (CD206/MRC1) contribute to tumor immunosuppression, angiogenesis, metastasis, and relapse.
- Molecular Weight:
- 158.6 kDa
- Physical State:
- Powder
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins