BAM 22P
About this Product
- SKU:
- PN-110
- CAS Number:
- 76622-26-9
- Extra Details:
- BAM 22P is a potent endogenous agonist, derived from the proenkephalin A gene, for the Mas-related G protein-coupled receptor X1 (MRGPRX1), which was originally isolated from bovine adrenal medulla. BAM 22P is a potent opioid agonist with an IC50 of 1.3 nM in guinea pig ileum. BAM 22P can produces opioid- and non-opioid receptor mediated antinociceptive effects in vivo.
- Molecular Weight:
- 2839.2
- Purity:
- >95% by HPLC
- References:
- <p>Mizuno et al (1980) A new family of endogenous "big" met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (BAM-22P) and eicosapeptide (BAM-20P) with very potent opiate activity. Biochem. Biophys. Res. Comm. <strong>97</strong>(4) 1283 <a href="https://pubmed.ncbi.nlm.nih.gov/7213356/" target="_blank" rel="nofollow">PMID: 7213356</a></p><p>Hong et al (2004) Dual effects of intrathecal BAM22 on nociceptive responses in acute and persistent pain - potential function of a novel receptor. Br.J.Pharmacol. <strong>141</strong> 423 <a href="https://pubmed.ncbi.nlm.nih.gov/14718254/" target="_blank" rel="nofollow">PMID: 14718254</a></p><p>Solinski et al (2014) Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev. <strong>66</strong> 570 <a href="https://pubmed.ncbi.nlm.nih.gov/24867890/" target="_blank" rel="nofollow">PMID: 24867890</a></p>
- Sequence:
- H-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-Gly-Arg-Pro-Glu-Trp-Trp-Met-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly-OH
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C130H184N38O31S2