A20FMDV2
About this Product
- SKU:
- IG-010
- Extra Details:
- A20FMDV2 is a peptide derived from the foot-and-mouth disease virus with a high affinity and selectivity for the alpha-v beta-6 (αvβ6) arginyl-glycinyl-aspartic acid (RGD)-binding integrin, inhibiting alphavbeta6-ligand binding with a IC50 of 3 nmol/L, an activity 1,000-fold more selective for alphavbeta6 than for other RGD-directed integrins (alphavbeta3, alphavbeta5, and alpha5beta1).
- Molecular Weight:
- 2162.5
- Purity:
- >95% by HPLC
- References:
- <p>Hausner et al (2007) Use of a Peptide Derived from Foot-and-Mouth Disease Virus for the Noninvasive Imaging of Human Cancer: Generation and Evaluation of 4-[18F]Fluorobenzoyl A20FMDV2 for In vivo Imaging of Integrin αvβ6 Expression with Positron Emission Tomography. Cancer Res.<strong> 67</strong>(16) 7833 <a href="https://pubmed.ncbi.nlm.nih.gov/17699789/" target="_blank" rel="nofollow">PMID: 17699789</a></p><p>Slack et al (2016) Pharmacological Characterization of the αvβ6 Integrin Binding and Internalization Kinetics of the Foot-and-Mouth Disease Virus Derived Peptide A20FMDV2. Pharmacology<strong> 97</strong>(3-4) 114 <a href="https://pubmed.ncbi.nlm.nih.gov/26734728/" target="_blank" rel="nofollow">PMID: 26734728</a></p>
- Sequence:
- H-Asn-Ala-Val-Pro-Asn-Leu-Arg-Gly-Asp-Leu-Gln-Val-Leu-Ala-Gln-Lys-Val-Ala-Arg-Thr-NH2
- Shipping Conditions:
- Ambient
- Storage Conditions:
- We recommend storage desiccated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble in water
- Formula:
- C93H164N32O27