Pexiganan
Product Sizes
Pexiganan
£200.00
AM-310
About this Product
- SKU:
- AM-310
- Additional Names:
- MSI 78
- CAS Number:
- 147664-63-9
- Extra Details:
Pexiganan (MSI 78) is a synthetic cationic peptide and an analogue of magainin 2, the host defence peptide isolated from the skin of the African frog Xenopus laevis. Pexiganan exhibits in vitro broad-spectrum antibacterial activity against many gram-positive and gram-negative, anaerobic and aerobic bacteria and is the first AMP developed into an antibacterial drug and the best-studied AMP to date for therapeutic purposes. Pexiganan shows a barrel-stave type mechanism of membrane disruption or channel formation and exerts its antibacterial effect by forming toroidal pores in bacterial membranes.
- Molecular Weight:
- 2477.21
- Purity:
- >95% by hplc
- References:
- <p>Lamb and Wiseman (1998) Pexiganan acetate. Drugs <strong>56</strong>(6) 1047 <a href="https://pubmed.ncbi.nlm.nih.gov/9878992/" target="_blank" rel="nofollow">PMID: 9878992</a></p><p>Gottler AND Ramamoorthy (2009) Structure, membrane orientation, mechanism, and function of pexiganan--a highly potent antimicrobial peptide designed from magainin. Biochim Biophys Acta. <strong>1788</strong>(8):1680 <a href="https://pubmed.ncbi.nlm.nih.gov/19010301/" target="_blank" rel="nofollow">PMID: 19010301</a></p><p>Rodríguez-Rojas et al (2020) Antimicrobial Peptide Induced-Stress Renders Staphylococcus aureus Susceptible to Toxic Nucleoside Analogs. Front Immunol. <strong>11</strong> 1686 <a href="https://pubmed.ncbi.nlm.nih.gov/33133056/" target="_blank" rel="nofollow">PMID: 33133056</a></p>
- Sequence:
- H-Gly-Ile-Gly-Lys-Phe-Leu-Lys-Lys-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Lys-Ile-Leu-Lys-Lys-NH2
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble in water
- Formula:
- C122H210N32O22