Magainin 2
Product Sizes
Magainin 2
£141.00
AM-101
About this Product
- SKU:
- AM-101
- CAS Number:
- 108433-95-0
- Extra Details:
- Magainins are closely related 23 amino acid amphipathic cationic peptides with broad-spectrum antimicrobial activities, originally extracted from the skin of the African clawed frog Xenopus laevis. Magainins 1 and magainin 2 are closely related hemolytic peptides which inhibit growth of bacteria by permeabilizing the cell membranes without significant toxicity against mammalian cells. The main target of magainin 1 and 2 is thought to be the lipid matrix of the membranes. Both magainin 1 and 2 are also cytotoxic to cancer cells and exhibit inhibitory action toward herpes simplex virus 1 and 2
- Molecular Weight:
- 2466.9
- Purity:
- >95% by HPLC
- References:
- <p>Zasloff (1987) Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc. Natl. Acad. Sci. <strong>84</strong>(15) 5449-5453 doi:10.1073/pnas.84.15.5449 </p><p>Thwaite et al (2009) The cationic peptide magainin II is antimicrobial for Burkholderia cepacia-complex strains. J. Med. Microbiol. <strong>58</strong> 923 https://doi.org/10.1099/jmm.0.008128-0 </p><p>Salnikov and Bechinger (2011) Lipid-controlled peptide topology and interactions in bilayers: structural insights into the synergistic enhancement of the antimicrobial activities of PGLa and magainin 2. Biophys J. <strong>100</strong>(6) 1473 doi: 10.1016/j.bpj.2011.01.070</p>
- Sequence:
- H-Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-Met-Asn-Ser-OH
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble in dilute acid
- Formula:
- C114H180N30O29S