Anti-Ubiquitin C Terminal Hydrolase 1 (UCHL1)
Product Sizes
100 ul
OAPC00081-100UL
About this Product
- SKU:
- OAPC00081
- Additional Names:
- NDGOA, PARK5, PGP95, SPG79, PGP9.5, Uch-L1, HEL-117, PGP 9.5, HEL-S-53
- Application:
- Immunofluorescence, Western Blot
- Buffer:
- Liquid. Contains 10 mM sodium azide.
- Clonality:
- Monoclonal
- Extra Details:
- Ubiquitin C-terminal hydrolase 1 (UCHL1) is also known as ubiquitin carboxyl esterase L1, ubiquitin thiolesterase, neuron-specific protein PGP9.5 and Park5. It was originally identified as a major component of the neuronal cytoplasm from 2-dimensional gel analysis of brain tissues, and was given the name PGP9.5 (1). It was later found that ubiquitin C-terminal hydrolase enzyme activity was associated with the PGP9.5 protein (2). The ubiquitin C-terminal hydrolases cleave ubiquitin from other molecules. Regulation of the ubiquitin pathway is very important and many disease states are associated with defects in this pathway. Genetic knockout of UCHL1 in mice results in a motor neuron degeneration similar to the spontaneous gracile axonal dystrophy (gad) mutant mice (3). Point mutations in the UCHL1 gene are associated with some forms of human Parkinson's disease (4). Since UCHL1 is heavily expressed in neurons, it is released in large amounts following injury or degeneration, so the detection of UCHL1 in CSF and other bodily fluids can be used as a biomarker.
- Formulation:
- Liquid. Contains 10 mM sodium azide.
- Host:
- Mouse
- Immunogen:
- Recombinant full length human UCHL1 purified from E. coli.
- Isotype:
- IgG1
- Molecular Weight:
- ~24kDa
- Physical State:
- Liquid
- Purification:
- Unpurified
- Reactivities:
- Bovine, Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Specificity:
- Specific for the ~24kDa UCHL1 protein.
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Aviva Systems Biology
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php