Anti-Clusterin (human) (CLI-9) Antibody
Product Sizes
100 ug
OAED00301-100UG
About this Product
- SKU:
- OAED00301
- Additional Names:
- AAG4;Aging-associated gene 4 protein;aging-associated protein 4;APOJ;APO-J;apolipoprotein J;CLI;CLU1;CLU2;clusterin;complement cytolysis inhibitor;complement lysis inhibitor;complement-associated protein SP-40,40;epididymis secretory sperm binding protein;ku70-binding protein 1;KUB1;NA1/NA2;SGP2;SGP-2;SP-40;sulfated glycoprotein 2;testosterone-repressed prostate message 2;TRPM2;TRPM-2.|clusterin
- Application:
- Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
- translate.label.attr.clone:
- CLI-9
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.
- Host:
- Mouse
- Immunogen:
- Purified human clusterin (TRPM-2).
- Isotype:
- IgG1
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- Recognizes human clusterin.
- Storage Conditions:
- 2-8[o]C Do not freeze. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php