HTRA1 Antibody
Product Sizes
HTRA1 Antibody
OACD04363
About this Product
- SKU:
- OACD04363
- Additional Names:
- ARMD7;CADASIL2;CARASIL;high-temperature requirement A serine peptidase 1;HtrA;IGFBP5-protease;L56;ORF480;protease, serine, 11 (IGF binding);PRSS11;Serine protease 11;serine protease HTRA1.|HtrA serine peptidase 1
- Application:
- Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
- Buffer:
- Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.
- Formulation:
- Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
- Host:
- Rabbit
- Immunogen:
- Range: Gly204 - Leu364
- Isotype:
- IgG
- Molecular Weight:
- 51 kDa
- Physical State:
- Liquid
- Purification:
- Affinity Purified; Protein A Purified
- Reactivities:
- Human, Porcine
- Shipping Conditions:
- Blue Ice
- Specificity:
- The antibody is a rabbit polyclonal antibody raised against HTRA1. It has been selected for its ability to recognize HTRA1 in immunohistochemical staining and western blotting.
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php