AMPKa1/AMPKa2 Polyclonal Antibody
Product Sizes
AMPKa1/AMPKa2 Polyclonal Antibody
RD265955A-200UL
About this Product
- SKU:
- RD265955A-200UL
- Additional Names:
- AMPKa1/AMPKa2
- Application:
- Immunofluorescence
- Buffer:
- PBS with 0.02% sodium azide, 50% glycerol, pH7.3
- Concentration:
- 1 mg/ml
- Extra Details:
- The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed./The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
- Host:
- Rabbit
- Immunogen:
- Recombinant protein of human PRKAA1/PRKAA2
- Isotype:
- IgG
- Protein Details:
- P54646, Q13131
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Size:
- 200 ul
- Supplier:
- Reddot
- Type:
- Antibody
- Synonyms:
- Acetyl-CoA carboxylase kinase;Hydroxymethylglutaryl-CoA reductase kinase;Tau-protein kinase PRKAA1
- Manufacturer's Data Sheet:https://www.reddotbiotech.ca/antibodies/product/32409/AMPKa1_AMPKa2_Polyclonal_Antibody/