Anti-Hu CD83 PE-Cy™5
Product Sizes
100 tests
AFC-4TKTK5-100TESTS
About this Product
- SKU:
- AFC-4TKTK5
- Additional Names:
- BL11, HB15
- Application:
- Flow Cytometry
- Buffer:
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- translate.label.attr.clone:
- HB15e
- Clonality:
- monoclonal
- Conjugate:
- PE/Cy5
- Extra Details:
- CD83 is a 40-45 kDa heavily glycosylated type I cell surface glycoprotein of immunoglobulin family. It is expressed on the surface of mature dendritic cells, Langerhans cells in the skin, and interdigitating reticulum cells in the lymphoid tissues. Low expression of CD83 has been reported in activated T and B cells. Cytoplasmic expression of CD83 can be detected also in monocytes and macrophages. CD83 is involved in modulation of antigen presentation. Soluble CD83 has immunoregulatory functions, it is able to down-regulate dendritic cell maturation and stimulation of T cells. In the developing immune system, release of soluble CD83 from dendritic cells upon stimulation by gram-positive or gram-negative bacteria has anti-allergic effect. Herpes simplex virus, on the other hand, causes CD83 degradation in mature dendritic cells.
- Format:
- PE-Cy™5
- Immunogen:
- Human CD83-transfected Cos cells
- Isotype:
- IgG1 k
- Purification:
- Purified antibody is conjugated with activated tandem dye of R-phycoerythrin-cyanine 5 (PE-Cy™5) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion
- Shipping Conditions:
- Blue Ice
- Specificity:
- The mouse monoclonal antibody HB15e recognizes an extracellular epitope of CD83, a 40-45 kDa type I glycoprotein expressed on mature dendritic cells.
- Storage Conditions:
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
- Supplier:
- Nordic BioSite
- Manufacturer's Data Sheet:Anti-Hu CD83 PE-Cy™5