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Antibodies

anti-alpha A Crystallin antibody

Product Sizes
100 ul
ARG59382-100UL
Academic Pricing
Please contact us for academic pricing.
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About this Product
SKU:
ARG59382
Additional Names:
CRYA1; HSPB4; CTRCT9
Application:
Immunocytochemistry, Immunofluorescence, Western Blot
Buffer:
PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
CE/IVD:
RUO
Clonality:
Polyclonal
Extra Details:
Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC). [provided by RefSeq, Jan 2014]
Host:
Rabbit
Immunogen:
Recombinant fusion protein corresponding to aa. 1-173 of Human alpha A Crystallin (NP_000385.1).
Isotype:
IgG
Purification:
Affinity Purified
Reactivities:
Fish, Human, Mouse, Rat
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C
Supplier:
Arigo Biolaboratories
Type:
Antibody: Polyclonal Antibody