Goat anti-Mouse IgM antibody (HRP), pre-adsorbed
About this Product
- SKU:
- ARG20576
- Additional Names:
- MU; VH; AGM1; Igm; muH; Igh6; Igh-6; Igh-M
- Application:
- ELISA, Flow Cytometry, IHC-Frozen, IHC-Paraffin, Immunocytochemistry, Immunofluorescence, Western Blot
- Buffer:
- 50% PBS (pH 7.4) and 50% Glycerol
- CE/IVD:
- RUO
- Clonality:
- Polyclonal
- Conjugate:
- HRP
- Extra Details:
- Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD; MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al., 2005).[supplied by OMIM, Aug 2010]
- Host:
- Goat
- Immunogen:
- Mouse IgM
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Specificity:
- The antibody reacts with the heavy chain of Mouse IgM. The antibody is pre-adsorbed with Mouse IgG and IgA, so the antibody may not react with Mouse IgG and IgA, but may react with immunoglobulins from other species.
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Arigo Biolaboratories
- Type:
- Antibody: Secondary Antibodies
- Manufacturer's Data Sheet:ARG20576.html
