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Antibodies

anti-alpha Synuclein antibody

Product Sizes
50 ul
ARG10689-50UL
Academic Pricing
Please contact us for academic pricing.
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About this Product
SKU:
ARG10689
Additional Names:
Non-A4 component of amyloid precursor; Alpha-synuclein; PARK4; PARK1; PD1; NACP; Non-A beta component of AD amyloid
Application:
IHC-Frozen, Immunocytochemistry, Immunofluorescence, Western Blot
Buffer:
PBS and 50% Glycerol.
CE/IVD:
RUO
Clonality:
Polyclonal
Concentration:
1 mg/ml
Extra Details:
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
Host:
Chicken/Avian
Immunogen:
Full length Human alpha Synuclein protein.
Isotype:
IgY
Purification:
Affinity Purified
Reactivities:
Avian, Bovine, Horse, Human, Mouse, Porcine, Rat
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C
Supplier:
Arigo Biolaboratories
Type:
Antibody: Polyclonal Antibody
Immunocytochemistry: Mixed Rat neuron-glial cultures stained with ARG10689 anti-alpha Synuclein antibody (red) and co-stained with monoclonal antibody to MAP2 (green). ARG10689 anti-alpha Synuclein antibody stains vesicular structures the perikarya and processes of the neurons in this image. Note that some of the neuronal perikarya contain much more alpha-synuclein than others. The blue channel shows the localization of DNA.
Immunohistochemistry: Frozen section of Rat cerebellum stained with ARG10689 anti-alpha Synuclein antibody (red) at 1:3000 dilution and costained with ARG52312 anti-GFAP antibody (green) at 1:5000 dilution. DAPI (blue) for nuclear staining. (Sample preparation: Following transcardial perfusion of Rat with 4% paraformaldehyde, brain was post fixed for 24 hours, cut to 45 uM, and free-floating sections were stained with above antibodies.)
Western blot: Crude extract of Rat brain stained with ARG10689 anti-alpha Synuclein antibody.
Western blot: Rat brain, Rat spinal cord, Mouse brain and Mouse spinal cord lysates stained with ARG10689 anti-alpha Synuclein antibody (green) at 1:2000 dilution.