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VMRD

VMRD's focus is on developing ELISA kits and antibodies for veterinary research and have created USDA-licensed diagnostic test kits for infectious disease agents such as Anaplasma spp., Babesia caballi, Babesia equi, Bovine Leukemia Virus, Bluetongue Virus, Small Ruminant Lentivirus, Equine Arteritis Virus, Equine Infectious Anemia Virus and Neospora caninum. Over time VMRD have developed other research reagents such as FA conjugates, IFA substrate and control slides, as well as a wide selection of monoclonal and polyclonal antibodies against infectious agents.

VMRD

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A new serology solution from VMRD for Johne’s disease

Johne’s disease is a chronic and highly contagious wasting disease of all ruminants caused by Mycobacterium avium ssp. paratuberculosis (MAP). Major clinical signs include weight loss, pipestream diarrhea, edema, decreased milk production, and eventually death.

In the US, Johne’s disease affects ~70% of dairy herds[1], costing the industry up to $250 million per year in production loss[2]. An estimated 5-10% of beef herds are also affected[3]. Currently, no effective vaccines or specific treatments are available, making proper diagnostic testing pivotal for management efforts.
[1] USDA. NAHMS - Dairy, 2008. [2] Ott SL, et al. Prev Vet Med, June 1999. [3] USDA. NAHMS - Beef, 1999.

Performance for validated samples
Bovine serum*

* USDA licensed

 

433 positive samples

VMRD: 93.1% Se, 90% Sp

261 negative samples

Competitor A: 91.0% Se, 85.4% Sp

(confirmed by fecal culture & PCR)

Competitor B: 86.6% Se, 89.3% Sp

User-friendly qualities
Speed and simplicity

  • No pre-incubation step for absorption
  • Results in <75 min
  • Ready-to-use conjugate and controls
  • Straightforward reagent preparation
  • Simple reagent identification by color
  • Reliable reagent consistency – no precipitation

Research data
Bovine milk

 

Sensitivity

Specificity

VMRD

84.7%

82.1%

Competitor A

73.6%

79.9%

Based on 59 positive and 224 negative samples with status confirmed by faecal culture and PCR

Research data
Caprine serum

 

Sensitivity

Specificity

VMRD

68.6%

100%

Competitor B

62.9%

100%

Competitor C

52.9%

100%

Based on 70 positive and 10 negative samples with status confirmed by necropsy

 

Sensitivity

Specificity

VMRD

100%

99.2%

Competitor A

92.6%

99.2%

Competitor B

100%

98.5%

Based on 27 positive and 129 negative samples with status confirmed by culture and/or PCR

Taking control of Johne’s Disease
with ELISA testing

  • Cost-effective for assessing herd prevalence and risk
  • Identifies target areas for focused management efforts
  • Highly sensitive nd specific for diagnosis of clinically affected animals

Validation data for Mycobacterium avium subsp paratuberculosis ELISA

Further information

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