(NLysNpheNphe)2-NH2

SKU:

PT-103

Extra Details:

Peptoids are peptide-mimicking poly-N-substituted glycines, which exhibit enhanced physiological stability and are known to have antibacterial and antiparasitic qualities. They have recently been shown to have activity against Leishmania mexicana axenic amastigotes. NLys is the N-(4-aminobutyl)glycine peptoid monomer and Nphe is the N-(phenylmethyl)glycine peptoid monomer

Molecular Weight:

862.1

Purity:

>90% by HPLC

References:

Chongsiriwatana et al (2008) Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides. Proc. Natl. Acad. Sci 105(8) 2794 DOI: 10.1073/pnas.0708254105

Zuckermann (2011) Peptoid origins. Biopolymers, 96 545 doi:10.1002/bip.21573

Sun and Zuckermann (2013) Peptoid Polymers: A Highly Designable Bioinspired Material. ACS Nano 7(6) 4715 https://doi.org/10.1021/nn4015714

Huang et al (2014) Learning from Host-Defense Peptides: Cationic, Amphipathic Peptoids with Potent Anticancer Activity. PLoS ONE 9(2) e90397. https://doi.org/10.1371/journal.pone.0090397

Eggimann et al (2015) Investigating the Anti-leishmanial Effects of Linear Peptoids. ChemMedChem. 10 233 doi:10.1002/cmdc.201402416

Sequence: