(KO Validated) MAP2K2 Polyclonal Antibody
Product Sizes
60 ul
E-AB-65103-60UL
120 ul
E-AB-65103-120UL
200 ul
E-AB-65103-200UL
About this Product
- SKU:
- E-AB-65103
- Additional Names:
- CFC4;MAPKK2;MEK2;MKK2;PRKMK2;MAP2K2
- Application:
- Western Blot
- Buffer:
- PBS
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide of human MAP2K2 (NP_109587.1).
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-(ko_validated)_map2k2_polyclonal_antibody-e_ab_65103