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Antibodies

TGFB1 Monoclonal Antibody

Product Sizes
20 ul
E-AB-22214-20UL
60 ul
E-AB-22214-60UL
120 ul
E-AB-22214-120UL
200 ul
E-AB-22214-200UL
About this Product
SKU:
E-AB-22214
Additional Names:
Cartilage-inducing factor;CED;Differentiation inhibiting factor;DPD1;LAP;Latency-associated peptide;Prepro transforming growth factor beta 1;TGF beta 1;TGF beta;TGF beta 1 protein;TGF-beta 1 protein;TGF-beta-1;TGF-beta-5;TGF-beta1;TGFB;Tgfb-1;tgfb1;TGFB1;TGFbeta;TGFbeta1;Transforming Growth Factor b1;Transforming Growth Factor beta 1;Transforming growth factor beta 1a;transforming growth factor beta-1;transforming growth factor;beta 1;Transforming Growth Factor-1
Application:
IHC-Paraffin, Immunohistochemistry
Buffer:
PBS
translate.label.attr.clone:
Clone:5D2
Clonality:
Monoclonal
Concentration:
1 mg/ml
Extra Details:
Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells.
Host:
Mouse
Immunogen:
Synthetic Peptide of TGFB Beta1
Isotype:
IgG
Purification:
Protein A Purified
Reactivities:
Mouse, Rat
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C Avoid freeze/thaw cycles.
Supplier:
Elabscience
Type:
Antibody: Monoclonal Antibody