anti-CD274 / PD-L1 antibody [12B4]
About this Product
- SKU:
- ARG11039
- Additional Names:
- Programmed cell death 1 ligand 1; B7-H1; B7H1; PDL1; PDCD1 ligand 1; B7 homolog 1; PD-L1; CD antigen CD274; PDCD1L1; B7-H; Programmed death ligand 1; PDCD1LG1
- Application:
- ELISA, Western Blot
- Buffer:
- PBS (pH 7.0)
- CE/IVD:
- RUO
- translate.label.attr.clone:
- 12B4
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- CD274 / PD-L1 is an immune inhibitory receptor ligand. It is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
- Host:
- Mouse
- Immunogen:
- Human cell expressed recombinant PD-L1 (Phe19-Arg238) with poly-histidine tag at C-terminus.
- Isotype:
- IgG1, kappa
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- Reactive with human programmed death ligand 1 (PD-L1).
- Storage Conditions:
- -20[o]C
- Supplier:
- Arigo Biolaboratories
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:ARG11039.html
