Alpha Synuclein pSer129 Monomers

Cannot supply to this region.

SKU:: SPR-520XE
Additional Names:: Alpha-synuclein, Alpha synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP, SNCA, PARK1, SYN, PD1, PARK4, Synuclein Alpha, Alpha Synuclein pSer129, Asyn
Application:: SDS-PAGE, WB, FuncS
Molecular Weight:: 14.46 kDa
Purity:: >95%
Purification:: Ion Exchange
Storage Conditions:: -70[o]C
Supplier:: StressMarq Biosciences
ABP:: No Import Docs
Buffer:: PBS
Immunogen:: Alpha Synuclein pSer129 Monomers
Species:: Human
Sequence:: MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Uniprot:: P37840
Synonyms:: alpha-synuclein;I+/--synuclein;NACP;non A-beta component of AD amyloid;Non-A beta component of AD amyloid;Non-A4 component of amyloid precursor;PARK1;PARK4;PD1;synuclein alpha-140;synuclein, alpha (non A4 component of amyloid precursor);truncated alpha synuclein
Extra Details:: Alpha-synuclein (A Alpha-synuclein), encoded by the SNCA gene, is a neuronal protein involved in synaptic vesicle trafficking, neurotransmitter release, and SNARE-complex assembly. In neurodegenerative diseases such as Parkinson's disease, A Alpha-synuclein undergoes pathological modifications, with phosphorylation at serine 129 (pSer129) being the most prominent post-translational change observed in aggregated forms within Lewy bodies. Phosphorylated A Alpha-synuclein at Ser129 is considered a biomarker of disease-associated aggregation and neurotoxicity. Monomeric pSer129 A Alpha-synuclein allows researchers to isolate and study the functional consequences of this specific modification. These monomers exhibit altered conformational dynamics, aggregation propensity, and cellular interactions compared to their non-phosphorylated counterparts. In neurodegenerative disease models, pSer129 monomers are used to investigate early misfolding events, membrane binding behavior, and the role of phosphorylation in promoting toxic oligomer formation. Their application supports mechanistic studies on synaptic dysfunction, mitochondrial impairment, and neuroinflammatory signaling pathways. Alpha-synuclein pSer129 monomers are also valuable in therapeutic screening platforms, enabling the evaluation of compounds that target phosphorylation-dependent aggregation or enhance clearance of modified A Alpha-synuclein. By replicating disease-relevant molecular features, these monomers accelerate translational research aimed at understanding and mitigating the progression of Parkinson's disease and related synucleinopathies. StressMarq's Alpha Synuclein Ser129 Monomers are generated in-house and phosphorylation confirmed with our anti-ASYN pS129 monoclonal antibody (catalog# SMC-600).

Shipping Conditions:: Dry Ice