Tau-441 (2N4R) Wild-Type Pre-formed Fibrils (Baculovirus/Sf9)

Cannot supply to this region.

SKU:: SPR-498
Additional Names:: MAPT, Tau, Tau-441, Tau40, 2N4R, intracellular neurofibrillary tangles, NFTs, paired helical filaments, PHFs, microtubule-associated Tau, Paired Helical Filament-Tau, Phf-Tau, tubulin-associated unit, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 2, Tau PFFs
Application:: SDS-PAGE, WB, FuncS
Concentration:: 2 mg/ml
Molecular Weight:: 45.84 kDa
Purity:: >95%
Purification:: Ion Exchange
Storage Conditions:: -70[o]C
Supplier:: StressMarq Biosciences
Buffer:: 1X PB pH7.4
Immunogen:: Tau-441 (2N4R) PFFs
Species:: Human
Sequence:: MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Uniprot:: P10636-8
Synonyms:: Neurofibrillary tangle protein;Paired helical filament-tau
Extra Details:: Tau-441, also known as the 2N4R isoform of the microtubule-associated protein tau (MAPT), is a full-length wild-type variant comprising 441 amino acids. It includes two N-terminal inserts and four microtubule-binding repeats, making it the longest isoform expressed in the adult human brain. Tau-441 plays a critical role in stabilizing neuronal microtubules and maintaining axonal integrity. However, under pathological conditions, Tau-441 can misfold and aggregate into B Beta-sheet-rich fibrillar structures, known as pre-formed fibrils (PFFs). These Tau-441 PFFs are increasingly recognized as key drivers of tauopathy progression, including Alzheimer's disease, frontotemporal dementia, and other neurodegenerative disorders. When introduced into cellular or animal models, Tau-441 PFFs seed endogenous tau aggregation, recapitulating hallmark features of disease pathology such as neurofibrillary tangles, synaptic dysfunction, and neuronal loss. Their ability to propagate pathology in a prion-like manner makes them a powerful tool for studying disease mechanisms and testing therapeutic interventions. Tau-441 PFFs serve as a reproducible and physiologically relevant model for investigating tau aggregation, neurotoxicity, and intercellular transmission. Their use in preclinical research accelerates the development of targeted therapies aimed at halting or reversing tau-driven neurodegeneration. StressMarq's Sf9/Baculovirus-expressed Tau 2N4R Pre-Formed Fibrils are generated without heparin.

Shipping Conditions:: Dry Ice