SPR-300
AHA1 Protein
Cannot supply to this region.
- SKU:
- SPR-300
- Additional Names:
- AHSA1, AHA1, HSPC322, p38, C14orf3, LOC10598, Activator of Hsp90 ATPase activity 1, Activator of 90 kDa heat shock protein ATPase homolog 1
- Application:
- SDS-PAGE, WB, FuncS
- Molecular Weight:
- ~38 kDa
- Purity:
- >90%
- Purification:
- Multi-step Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- ABP:
- No Import Docs
- Buffer:
- 20mM HEPES buffer pH7.2, 80mM NaCl, 10% glycerol
- Immunogen:
- AHA1 Protein
- Species:
- Human
- Sequence:
- SHMAKWGEGDPRWIVEERADATNVNNWHWTERDASNWSTDKLKTLFLAVQVQNEEGKCEVTEVSKLDGEASINNRKGKLIFFYEWSVKLNWTGTSKSGVQYKGHVEIPNLSDENSVDEVEISVSLAKDEPDTNLVALMKEEGVKLLREAMGIYISTLKTEFTQGMILPTMNGESVDPVGQPALKTEERKAKPAPSKTQARPVGVKIPTCKITLKETFLTSPEELYRVFTTQELVQAFTHAPATLEADRGGKFHMVDGNVSGEFTDLVPEKHIVMKWRFKSWPEGHFATITLTFIDKNGETELCMEGRGIPAPEEERTRQGWQRYYFEGIKQTFGYGARLF
- Uniprot:
- O95433
- Synonyms:
- activator of 90 kDa heat shock protein ATPase homolog 1;AHA1;AHA1, activator of heat shock 90kDa protein ATPase homolog 1;C14orf3;hAha1;p38
- Extra Details:
- AHA1 (Activator of HSP90 ATPase 1) is a co-chaperone that enhances the ATPase activity of HSP90, accelerating its chaperone cycle and modulating the folding of client proteins. In the nervous system, AHA1 plays a critical role in regulating the stability and function of proteins involved in synaptic signaling, neuronal development, and stress responses. In neurodegenerative diseases, AHA1 has been implicated in the processing of aggregation-prone proteins such as tau and huntingtin. By stimulating HSP90 activity, AHA1 can influence the folding and degradation of these proteins, potentially affecting their accumulation and toxicity. Dysregulation of AHA1 expression or function may contribute to proteostasis imbalance, a hallmark of disorders like Alzheimer's and Huntington's disease. AHA1's role in modulating the chaperone machinery makes it a promising target for therapeutic strategies aimed at restoring protein homeostasis in neurodegeneration. Its activity may also serve as a biomarker for cellular stress and chaperone system dynamics in the aging brain.
- Shipping Conditions:
- Blue Ice