GRP78 (Bip) Protein

Cannot supply to this region.

SKU:: SPR-107
Additional Names:: BiP, GRP78, HSPA5, MIF2, Immunoglobulin heavy chain binding
Application:: ELISA, SDS-PAGE, WB, FuncS
Molecular Weight:: ~78 kDa
Purity:: >90%
Purification:: Affinity Purified
Storage Conditions:: -20[o]C
Supplier:: StressMarq Biosciences
ABP:: No Import Docs
Buffer:: 50mM Tris/HCl, pH 7.5, 150mM NaCl, 10% glycerol
Immunogen:: GRP78 Protein
Species:: Human
Sequence:: MKLSLVAAMLLLLSAARAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALSSQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGTFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEEKIEWLESHQDADIEDFKAKKKELEEIVQPIISKLYGSAGPPPTGEEDTAEKDEL
Uniprot:: P11021
Synonyms:: 78 kDa glucose-regulated protein;binding-immunoglobulin protein;BIP;endoplasmic reticulum chaperone BiP;endoplasmic reticulum lumenal Ca(2+)-binding protein grp78;epididymis secretory sperm binding protein Li 89n;glucose-regulated protein, 78kDa;GRP78;heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa);heat shock protein 70 family protein 5;heat shock protein family A member 5;HEL-S-89n;HSP70 family protein 5;immunoglobulin heavy chain-binding protein
Extra Details:: GRP78, also known as BiP (Binding Immunoglobulin Protein), is a key endoplasmic reticulum (ER) chaperone involved in protein folding, quality control, and the unfolded protein response (UPR). It is a member of the HSP70 family and is upregulated during ER stress to maintain cellular homeostasis. In neuroscience, GRP78 plays a protective role against ER stress-induced apoptosis, a common feature in neurodegenerative diseases such as Alzheimer's, Parkinson's, and ALS. Neurons are particularly sensitive to disruptions in protein folding, and GRP78 helps mitigate this by stabilizing misfolded proteins and regulating UPR signaling pathways. Reduced GRP78 expression has been observed in the brains of Alzheimer's patients, correlating with increased protein aggregation and neuronal loss. Conversely, upregulation of GRP78 has been shown to confer neuroprotection in models of glutamate toxicity and oxidative stress. GRP78 also influences neurodevelopment and synaptic plasticity, making it a critical factor in both disease and normal brain function. Its role in modulating ER stress responses positions it as a potential biomarker and therapeutic target for neurodegenerative and neuroinflammatory disorders.

Shipping Conditions:: Blue Ice