SPC-816D-APC
Amyloid Beta Aggregate Antibody: APC
Cannot supply to this region.
- SKU:
- SPC-816D-APC
- Additional Names:
- Amyloid beta A4 protein (APP), AB Beta aggregates, Amyloid-beta aggregates, AB Beta42 oligomers, AB Beta42 fibrils, B Beta-sheet fibrils, AB Beta seeds, AB Beta, Abeta, Beta-amyloid
- Application:
- IHC, WB, Dot blot
- Concentration:
- 1 mg/ml
- Species Reactivity:
- Human
- Purification:
- Protein A Purified
- Storage Conditions:
- See Manual
- Supplier:
- StressMarq Biosciences
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- 95.46mM Phosphate, 2.48mM MES and 2mM EDTA
- Immunogen:
- Amyloid Beta 1-42 Oligomers (SPR-488)
- Uniprot:
- P05067
- Synonyms:
- AAA;ABETA;ABPP;AD1;alpha-sAPP;alzheimer disease amyloid protein;amyloid beta (A4) precursor protein;amyloid beta A4 protein;amyloid precursor protein;amyloid-beta precursor protein;APPI;beta-amyloid peptide;beta-amyloid peptide(1-40);beta-amyloid peptide(1-42);beta-amyloid precursor protein;cerebral vascular amyloid peptide;CTFgamma;CVAP;peptidase nexin-II;PN-II;PN2;preA4;protease nexin-II;testicular tissue protein Li 2
- Extra Details:
- Amyloid beta (AB Beta) aggregates are key drivers of Alzheimer's disease pathology, with soluble AB Beta42 assemblies inducing inflammation and microglial activation even at early disease stages. These aggregates disrupt neuronal homeostasis, synergize with tau pathology, and promote neuroinflammatory cascades that accelerate neurodegeneration. Emerging evidence also suggests that AB Beta may exert context-dependent protective functions, such as metal chelation, with neurotoxicity arising when these compensatory mechanisms become overwhelmed. Collectively, these findings position AB Beta aggregation as a central mechanistic and therapeutic target in neurodegenerative disease research. StressMarq's Rabbit-Anti-Amyloid Beta Aggregate Polyclonal Antibody has been shown to demonstrate higher affinity to aggregated forms over APP or monomers.
- Shipping Conditions:
- Blue Ice