SPC-762
ROR1 Antibody
Cannot supply to this region.
- SKU:
- SPC-762
- Additional Names:
- ROR 1, NTRKR1, Neurotrophic tyrosine kinase, OTTMUSP00000008344, Receptor tyrosine kinase like orphan receptor 1, Neurotrophic tyrosine kinase receptor related 1, RP11 24J23.1, Inactive tyrosine-protein kinase transmembrane receptor ROR1, Tyrosine protein kinase transmembrane receptor ROR1, ROR1_HUMAN, Tyrosine-protein kinase transmembrane receptor ROR1, Tyrosine kinase like orphan receptor 1, OTTHUMP00000010574, ROR1, RGD1559469, Neurotrophic tyrosine kinase, receptor related 1,
- Application:
- IHC, WB
- Concentration:
- 1 mg/ml
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- ABP:
- IMP-GEN-2015-06 < 10% Serum <100ml
- Buffer:
- PBS pH 7.4, 50% glycerol, 0.09% sodium azide
- Immunogen:
- Synthetic peptide from the mid-protein of Human ROR1 (aa. 200-300)
- Uniprot:
- Q01973
- Synonyms:
- dJ537F10.1;inactive tyrosine-protein kinase transmembrane receptor ROR1;neurotrophic tyrosine kinase, receptor-related 1;NTRKR1
- Extra Details:
- Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the ROR family of transmembrane proteins involved in non-canonical Wnt signaling. While ROR1 is best known for its role in embryonic development and cancer biology, emerging evidence highlights its significance in the nervous system, particularly in the context of neurodegenerative diseases. In the adult brain, ROR1 expression is typically low but becomes upregulated in response to injury or pathological stress. Recent studies have shown that ROR1 can counteract cytoskeletal degradation induced by amyloid-beta (AB Beta1-42), a hallmark of Alzheimer's disease. Overexpression of ROR1 in neuronal models preserves actin filament integrity, promotes neuritogenesis, and mitigates AB Beta-induced cytoskeletal instability. ROR1 is also regulated by non-coding RNAs, including miR-146a and NEAT1, which are dysregulated in Alzheimer's disease. This regulatory axis suggests that ROR1 is part of a broader epigenetic network influencing neuronal structure and resilience. Additionally, ROR1-mediated signaling may support axonal growth, synaptic maintenance, and neuroregeneration through Wnt5a-dependent pathways. Given its role in maintaining cytoskeletal architecture and responding to neurotoxic stress, ROR1 represents a promising therapeutic target for neurodegenerative diseases. Modulating ROR1 expression or activity could offer novel strategies to preserve neuronal integrity and slow disease progression.
- Shipping Conditions:
- Blue Ice