SPC-682
p53 Antibody
Cannot supply to this region.
- SKU:
- SPC-682
- Additional Names:
- TP53, Tumor Protein 53, BCC7, LFS1, TRP53, p53 tumor suppressor
- Application:
- WB, IF, ICC
- Concentration:
- 1 mg/ml
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Host:
- Rabbit
- Reactivities:
- Human
- ABP:
- IMP-GEN-2015-06 < 10% Serum <100ml
- Buffer:
- PBS, 50% glycerol, 0.09% sodium azide
- Immunogen:
- Synthetic peptide from the C-terminal of human tumor protein p53.
- Uniprot:
- P04637
- Synonyms:
- antigen NY-CO-13;BCC7;BMFS5;cellular tumor antigen p53;LFS1;mutant tumor protein 53;P53;p53 tumor suppressor;phosphoprotein p53;transformation-related protein 53;TRP53;tumor protein 53;Tumor suppressor p53;tumor supressor p53
- Extra Details:
- p53 (tumor protein 53) is a transcription factor best known for its role in tumor suppression, but it also plays a critical role in neuronal survival, DNA repair, and apoptosis. Often referred to as the "guardian of the genome," p53 maintains genomic stability by regulating cell cycle checkpoints and initiating cell death in response to DNA damage. In the brain, p53 is activated by oxidative stress, excitotoxicity, and mitochondrial dysfunction-key features of neurodegenerative diseases. Overactivation of p53 can lead to excessive neuronal apoptosis, contributing to the progression of Alzheimer's, Parkinson's, and Huntington's disease. Targeting p53 signaling pathways offers a promising strategy to modulate neuronal death and enhance neuroprotection in degenerative conditions.
- Shipping Conditions:
- Blue Ice