Rab5 Antibody: APC

Cannot supply to this region.

SKU:: SPC-168D-APC
Additional Names:: Rab 5A, RAS associated protein RAB5A, Ras related protein Rab 5 A
Application:: IHC, WB, IF, ICC
Concentration:: 1 mg/ml
Species Reactivity:: Human
Purification:: Protein A Purified
Storage Conditions:: See Manual
Supplier:: StressMarq Biosciences
Host:: Rabbit
Reactivities:: Bovine, Human, Mouse, Rat
ABP:: IMP-GEN-2015-06 < 10% Serum <100ml
Buffer:: 95.46mM Phosphate, 2.48mM MES and 2mM EDTA
Immunogen:: Human Rab5 synthetic peptide conjugated to KLH; identical to dog Rab5 sequence over the residues
Uniprot:: P20339
Synonyms:: RAB5;RAS-associated protein RAB5A;ras-related protein Rab-5A
Extra Details:: Rab5 is a 24 kDa GTPase that regulates early endosome dynamics and endocytic trafficking. It is ubiquitously expressed and localizes to early endosomes and the plasma membrane. Rab5 controls the fusion of endocytic vesicles with early endosomes and mediates homotypic endosome fusion. It recruits effectors such as EEA1 and Rabaptin-5 to facilitate vesicle docking and fusion. In the nervous system, Rab5 is essential for receptor internalization, synaptic vesicle recycling, and neurotrophin signaling. Dysregulation of Rab5 activity can lead to endosomal dysfunction, impaired signaling, and neurodegeneration. It is widely used as a marker of early endosomes and is a key player in maintaining neuronal homeostasis.