SPC-154
Phosphothreonine Antibody
Cannot supply to this region.
- SKU:
- SPC-154
- Additional Names:
- O-phospho-L-threonine, Phospho-threonine
- Application:
- ELISA, WB, IF, ICC, IP
- Concentration:
- 0.25 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Host:
- Rabbit
- ABP:
- IMP-GEN-2015-06 < 10% Serum <100ml
- Buffer:
- PBS, 50% glycerol, 0.01% sodium azide
- Immunogen:
- Phosphothreonine conjugated to KLH
- Extra Details:
- Phosphothreonine is a phosphorylated derivative of threonine, catalyzed by serine/threonine kinases. It serves as a regulatory switch in numerous signaling pathways that govern neuronal survival, synaptic function, and stress responses. In the brain, phosphothreonine modifications influence the activity of key proteins such as tau, MAPKs, and transcription factors. Dysregulated threonine phosphorylation is associated with protein misfolding, impaired axonal transport, and neuroinflammation-hallmarks of neurodegenerative diseases. Notably, abnormal phosphorylation of tau at threonine residues contributes to its aggregation and toxicity in Alzheimer's disease. As a modifiable and site-specific event, phosphothreonine is a valuable marker for disease progression and a potential target for kinase-based therapies in neurodegeneration.
- Shipping Conditions:
- Blue Ice